Synthesis and Characterization of 3-Phenyl-adamantane-1-carboxylic Acid |
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| Authors: | FENG Wei YE Kaiqi JIANG Yang HOU Ruibin |
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| Institution: | 1. China-Japan Union Hospital of Jilin University, Changchun 130033, P. R. China;2. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China;3. Advanced Institute of Materials Science, College of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, P. R. China |
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| Abstract: | Adamantane and its derivatives have been introduced into many drugs for current clinical research and some of them are used for the treatment of neurological disease and/or used as the antiviral agents as well as the agents against type-2 diabetes. Recently, there have been many relevant research reported for developing medicinal chemistry by employing the adamantyl group. In this paper, a new adamantane-based compound (3-phenyl-adaman-tane-1-carboxylic acid, PACA) was synthesized and characterized by X-ray diffraction(XRD), thermogravimeric analysis(TGA), Fourier transform infrared spectroscopy(FTIR), etc., which should be a beneficial complement or extension to the existing adamantyl-based materials. |
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| Keywords: | Adamantane Cage-like molecule Medicinal chemistry Single crystal |
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