聚N-异丙基丙烯酰胺温敏水凝胶的研究与应用进展

温敏水凝胶能够对温度的改变进行响应,在实际应用中备受关注。其中,聚N-异丙基丙烯酰胺(PNIPAM)由于温敏性良好、制备简单、易于修饰等优点,是研究和应用最为广泛的一种温敏水凝胶。近年来,随着研究的进一步深入,特别是化学改性和修饰技术的进步,各种具有优异响应性能的新型PNIPAM温敏水凝胶不断出现,其应用的深度和广度不断扩展和更新.更为贴近实际需求,在生物医药、化学化工等领域前景广阔。本文介绍了PNIPAM温敏水凝胶的温敏性原理及主要的制备方法,重点综述了其在药物释放、细胞支架、传感分析和物质分离等方面的应用现状和发展趋势,对其存在的问题及发展前景进行了分析和展望,为PNIPAM温敏水凝胶的进一步发展提供借鉴和参考。

The Research and Application Progress of Poly(N-isopropylacrylamide) Thermosensitive Hydrogels

Thermosensitive hydrogels can respond to the change of temperature and attract much attention in practical applications. Among them, poly ( N-isopropylacrylamide)( PNIPAM ) is one of the most widely studied and applied thermosensitive hydrogels because of its good thermosensitivity, simple preparation and easy modification. In recent years, with the further development of research, especially the progress of chemical modification and functionalization technology, a variety of novel PNIPAM thermosensitive hydrogels with excellent response performance have emerged. The depth and breadth of their applications have been expanded and updated, which are more close to the actual needs. So PNIPAM thermosensitive hydrogels have broad prospects in the fields of biomedicine, chemical industry and so on. In this article, the principle of thermosensitivity and main preparation methods of PNIPAM hydrogels are introduced. The application situation and development trend of PNIPAM hydrogels in drug release, cell scaffold, sensor analysis and material separation are discussed. The existing problems and development prospects of PNIPAM hydrogels are analyzed and prospected. This review could provide a reference for the further development of PNIPAM thermosensitive hydrogels.