Visible-light-driven palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade |
| |
| Authors: | Li Chen Li-Na Guo Shuai Liu Le Liu Xin-Hua Duan |
| |
| Institution: | School of Chemistry, Xi''an Key Laboratory of Sustainable Energy Material Chemistry, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter Xi''an Jiaotong University, Xi''an Shaanxi 710049 China ; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou730000 P. R. China, |
| |
| Abstract: | A visible-light-induced palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade is described. A range of six to nine-membered β-alkenylated cyclic ketones possessing a quaternary carbon center were accessed under mild conditions. Besides styrenes, the electron-rich alkenes such as silyl enol ethers and enamides were also compatible, providing the desired β-alkylated cyclic ketones in moderate to good yields.An intermolecular Dowd–Beckwith ring expansion/C–C bond formation is achieved through light-induced palladium catalysis. Not only styrenes but also the electron-rich alkenes such as silyl enol ethers and enamides were also compatible in this reaction. |
| |
| Keywords: | |
|
|
