Correction: Iridium-catalyzed enantioselective olefinic C(sp2)–H allylic alkylation |
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Authors: | Rahul Sarkar Santanu Mukherjee |
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Affiliation: | Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012 India, Fax: +91-80-2360-0529, +91-80-2293-2850 |
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Abstract: | The first iridium-catalyzed enantioselective olefinic C(sp2)–H allylic alkylation is developed in cooperation with Lewis base catalysis. This reaction, catalyzed by cinchonidine and an in situ generated cyclometalated Ir(i)/phosphoramidite complex, makes use of the latent enolate character of an α,β-unsaturated carbonyl compound, namely coumalate ester, to introduce an allyl group at its α-position in a branched-selective manner in moderate to good yield with good to excellent enantioselectivities (up to 98 : 2 er).The first iridium-catalyzed enantioselective allylic alkylation of an olefinic C(sp2)–H bond – that of an α,β-unsaturated carbonyl compound, is developed in cooperation with Lewis base catalysis. |
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