(2S)‐2‐[1‐(2,4‐Difluoro‐5‐iodophenyl)‐2‐deoxy‐β‐d‐ribofuranos‐5‐yloxy]‐8‐methyl‐4H‐1,3,2‐benzodioxaphosphole 2‐oxide |
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Authors: | Kazue Ohkura Wei Yan Sun Koh‐ichi Seki Edward E Knaus Leonard I Wiebe |
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Abstract: | The title compound, C19H18F2IO6P, prepared as a potential antiviral and anticancer agent from 3‐methylsalicylchlorophosphane and 1‐(2,4‐difluoro‐5‐iodophenyl)‐2‐deoxy‐β‐d ‐ribofuranose, is one of a 1:1 mixture of two diastereomers. The diastereomers differ in their configuration, S or R, at the asymmetric phosphorus center. X‐Ray crystallographic analysis of the title compound has determined the absolute configuration at the asymmetric P center to be S. |
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