Mechanochemical reactivity inhibited,prohibited and reversed by liquid additives: examples from crystal-form screens |
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| Authors: | Mihails Arhangelskis Dejan-Kre&#x;imir Bu
ar Simone Bordignon Michele R Chierotti Samuel A Stratford Dario Voinovich William Jones Dritan Hasa |
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| Institution: | Faculty of Chemistry, University of Warsaw, 1 Pasteura Street, Warsaw 02-093 Poland ; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ UK.; Department of Chemistry and NIS Centre, University of Turin, Via Giuria 7, Torino 10125 Italy ; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW UK ; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste Italy, |
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| Abstract: | We demonstrate that liquid additives can exert inhibitive or prohibitive effects on the mechanochemical formation of multi-component molecular crystals, and report that certain additives unexpectedly prompt the dismantling of such solids into physical mixtures of their constituents. Computational methods were employed in an attempt to identify possible reasons for these previously unrecognised effects of liquid additives on mechanochemical transformations.Liquid additives can exert catalytic, inhibitive or prohibitive effects on the mechanochemical formation of multi-component molecular crystals. |
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