A pH reversibly activatable NIR photothermal/photodynamic-in-one agent integrated with renewable nanoimplants for image-guided precision phototherapy |
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Authors: | Xu Zhao Kai-Chao Zhao Li-Jian Chen Yu-Shi Liu Jia-Lin Liu Xiu-Ping Yan |
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Institution: | State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122 China.; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122 China ; Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122 China ; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122 China |
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Abstract: | Phototherapy has great potential to revolutionize conventional therapeutic modalities. However, most phototherapeutic strategies based on multicomponent therapeutic agents generally lack tumor-specificity, resulting in asynchronous therapy and superimposed side-effects. Severe heat damage is also inevitable because of the necessity of continuous external irradiation. Here we show the design of an acid-activated and continuous external irradiation-free photothermal and photodynamic (PTT/PDT) synchronous theranostic nanoplatform for precision tumor-targeting near-infrared (NIR) image-guided therapy. pH-reversibly responsive brominated asymmetric cyanine is designed as the tumor-specific NIR PTT/PDT-in-one agent to enhance anticancer efficiency and reduce side-effects. Ultra-small NIR persistent luminescence nanoparticles are prepared as both the imaging unit and renewable nanoimplant. Biotin functionalized polyethylene glycol is introduced to endow active tumor-targeting ability and prolong blood-circulation. The developed smart platform offers merits of reversible activation, PTT/PDT synergetic enhancement, tumor targetability and continuous external irradiation-free properties, allowing autofluorescence-free image-guided phototherapy only in tumor sites. This work paves the way to developing smart theranostic nanoplatforms for precision medicine.A smart NIR photothermal/photodynamic-in-one agent integrated with renewable nanoimplants for autofluorescence- and continuous external irradiation-free image-guided precision tumor-targeting phototherapy. |
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