(R)‐4‐(4‐Fluorophenyl)‐1‐[2‐hydroxy‐2‐(3‐methyl‐1‐benzofuran‐2‐yl)ethyl]piperazinium chloride propan‐1‐ol solvate |
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Authors: | Pavel Kurfü rst,Jaromí r Marek,Já n Vanč o,Jozef Csö llei |
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Abstract: | The title compound, C21H24FN2O2+·Cl−·C3H8O, is a potential drug designed as a hybrid compound with antihypertensive, antioxidant and β‐adrenolytic activity. The cation contains nearly planar benzofuran and fluorophenyl ring systems, as well as a piperazine ring adopting an almost perfect chair conformation. The benzofuran and piperazine moieties are connected by an ethyl chain, the moieties forming a dihedral angle of 163.12 (13)°. In the crystal structure, ions and propanol solvent molecules are linked via N—H⋯Cl and O—H⋯Cl bonds into linear (010) chains. |
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