A chiroptical approach for the absolute stereochemical determination of P-stereogenic centers |
| |
| Authors: | Debarshi Chakraborty Hadi Gholami Aritra Sarkar Leo A. Joyce James E. Jackson Babak Borhan |
| |
| Affiliation: | Michigan State University, Department of Chemistry, East Lansing MI 48824 USA.; Department of Process Research and Development, Merck and Co, Inc., Rahway NJ 07065 USA |
| |
| Abstract: | A simple chiroptical solution for the absolute stereochemical determination for asymmetric phosphorus V stereocenters is presented. Strong coordination of the phosphorus oxide with the Zn-metallo center of the racemic host Zn-MAPOL 2 leads to an induced axial chirality of the host, yielding a strong ECCD signal. A mnemonic is proposed to correlate the asymmetry of the guest molecule with the observed ECCD signal.A simple chiroptical solution for the absolute stereochemical determination for asymmetric phosphorus V stereocenters is presented. |
| |
| Keywords: | |
|
|
