Carbon monoxide and hydrogen (syngas) as a C1-building block for selective catalytic methylation |
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Authors: | Akash Kaithal Markus Hlscher Walter Leitner |
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Institution: | Max Planck Institute for Chemical Energy Conversion, Stiftstraße 34-36, Mülheim a.d. Ruhr 45470 Germany.; Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringer Weg 2, 52074 Aachen Germany |
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Abstract: | A catalytic reaction using syngas (CO/H2) as feedstock for the selective β-methylation of alcohols was developed whereby carbon monoxide acts as a C1 source and hydrogen gas as a reducing agent. The overall transformation occurs through an intricate network of metal-catalyzed and base-mediated reactions. The molecular complex Mn(CO)2BrHN(C2H4PiPr2)2]] 1 comprising earth-abundant manganese acts as the metal component in the catalytic system enabling the generation of formaldehyde from syngas in a synthetically useful reaction. This new syngas conversion opens pathways to install methyl branches at sp3 carbon centers utilizing renewable feedstocks and energy for the synthesis of biologically active compounds, fine chemicals, and advanced biofuels.A broadly applicable catalytic process for the selective β-methylation of alcohols is presented using syngas (CO/H2) directly as a C1 building block and the shown manganese complex in the presence of a base as the catalytic system. |
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