Water as the reaction medium in organic chemistry: from our worst enemy to our best friend |
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| Authors: | Margery Cortes-Clerget Julie Yu Joseph R A Kincaid Peter Walde Fabrice Gallou Bruce H Lipshutz |
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| Institution: | Chemical & Analytical Development, Novartis Pharma AG, 4056 Basel Switzerland.; Department of Materials, ETH Zurich, Zurich Switzerland ; Department of Chemistry & Biochemistry, University of California, Santa Barbara California 93106 USA |
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| Abstract: | A review presenting water as the logical reaction medium for the future of organic chemistry. A discussion is offered that covers both the “on water” and “in water” phenomena, and how water is playing unique roles in each, specifically with regard to its use in organic synthesis.A review that highlights water as the logical reaction medium in which organic chemistry can be practiced. The key roles that water can play in directing reaction outcomes, including impacting mechanistic features, are discussed using selected examples. |
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