3β,6β‐Dihydroxyolean‐12‐en‐27‐oic acid: a cytotoxic and apoptosis‐inducing oleanane triterpenoid from the rhizome of Astilbe chinensis |
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Authors: | Hong‐Xiang Sun Yuan‐Jiang Pan |
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Abstract: | 3β,6β‐Dihydroxyolean‐12‐en‐27‐oic acid, C30H48O4, a cytotoxic and apoptosis‐inducing oleanane triterpenoid, which was isolated from the rhizome of Astilbe chinensis, consists of a linear array of five fused six‐membered rings. The central ring has a slightly distorted half‐chair conformation, while the four outer rings adopt chair conformations. Two hydroxy groups and one carboxy group serve simultaneously as hydrogen‐bond donors and acceptors, forming molecular chains. |
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