Non-Aqueous Titrimetric Determination of Sulphadimidine Sodium and Sulphadiazine Sodium in Injections

Abstract

The behaviour of sodium salts of two heterocyclic sulphonamide derivatives (Sulphadimidine and sulphadiazine) in non-aqueous titrimetry was studied. Accordingly a simple and accurate procedure for their determination, based on their titration in acetic anhydride-acetic acid solvent system (5:1) with acetous perchloric acid solution is proposed. Results obtained agreed with those of a pharmacopoeial method.