Photometric Flow Injection Determination of Psychotropic Drugs: Brotizolam and Midazolam

Abstract

Brotizolam and Midazolam, psychotropic drugs belonging to thienotriazolodiazepine and imidazobenzodiazepine families, have been determined by flow injection analysis with photometric detection. At pH 7, signals showed to be rectilinear from 1.27 × 10^?6M to 1.07 × 10^?4 M for brotizolam and from 1.53 × 10^?6 M to 1.07 × 10^?4M for midazolam. Methods developed were applied to the determination of both drugs in their formulations (Lendormin and Dormicum).