Abstract: | Abstract Some original histamine membrane sensors were prepared by incorporating thiopyrilium (TP) derivative as an excellent charged carrier. Among these sensors, TP2 shows the best response to histamine in a wide concentration range from 2.5×10?6 to 1.0×10?1 mol L?1 with a slope of 55.6±0.7 mV decade?1 and with a detection limit of 1.0 µmol L?1 (~0.1 ppm). The interference between histamine and several amino acids and common inorganic anions was negligible as shown by the potentiometric selectivity coefficient data. The prepared electrode was used for the determination of histamine in a human serum synthetic sample. Theoretical calculations were carried out to find the best interactions between histamine and different ligands. |