Determination Of Nucleic Acid Bases At Nanomolar Concentrations By Means Of Cathodic Stripping Voltammetry

Abstract

It is shown that nucleic acid bases and some of their derivatives can be determined by means of cathodic stripping voltammetry (CSV). The limit of detection of adenine is about 2 × 10^?9 M. Presence of an excess of DNA does not interfere with the determination of free bases. CSV may be used also for the determination of nucleosides and nucleotides derived from purine bases.