| Abstract: | Abstract The third derivative spectrophotometric method has been proposed for the determination of metomidate from aqueous solution. By hydrolysis of metomidate, D,L-l-(l-phenylethyl)-imidazole-5-carboxylic acid is formed. Determining the absolute value of the third derivative spectra in the “zero-crossing” point, the concentration of metomidate can be calculated directly without any interferences. The validity of the method was confirmed using synthetic mixtures. Kinetic investigation of the degradation rate of metomidate revealed that the proposed method is stability indicating. |
