| Abstract: | Abstract The study on interaction of dsDNA with the combination of methotrexate and emodin demonstrated that emodin and methotrexate can form intermolecular hydrogen bonds that enhance the anticancer effect of methotrexate and decrease the side effects. The results show that a combination of synthetic and herbal medicines in treating cancer is very effective and can be used to select other effective combination uses of antitumor drugs. At the same time, according to different interaction models of methotrexate with dsDNA and ssDNA, methotrexate can be used to discriminate between dsDNA and ssDNA in a DNA biosensor as hybridization indicator. |
