| Abstract: | Abstract Two proposed methods have been described for the determination of prenalterol hydrochloride in acetate buffer (pH=4.1) as authentic material and in tablets form using a (i) colorimetric method based on reduction of ferric iron by prenalterol hydrochloride and subsequent measurement at 511 nm of the red color obtained by the treatment of the resultant ferrous iron with 1, 10-orthophenanthroline, (ii) a differential pulse polarographic method based on nitrosation with 0.1 M NaNO2/dil. HC1 and consequent recording of the differential pulse polarogram. The differential polarogram was obtained under constant amplitude pulses of 50 mV (DP 50) superimposed on a linearly increasing DC-voltage ramp. The peak height (h), of the polarogram was measured at the peak potential of -0.2V on the dropping mercury electrode (DME) versus Ag/AgCl reference electrode. The linearity ranges observed are 0.6μgfml to 6.0μg/ml and 2μg/ml to 12μg/ml, respectively. The mean percentage recoveries for an authentic sample are 99.5±1.4 and 100.5±0.7, respectively. When applied to tablets claimed to contain 10 mg each, the mean percentages obtained are 99.7±2.3 and 100.6 ±1.5 respectively. |
