Abstract: | Abstract This work demonstrates the electrochemical behavior of the 1-phenyl-3-methyl-4-(α-furoyl)-pyrazolone-5 (HPMαFP) modified glassy carbon electrode (HPMαFP/GCE) by a dropletting method. Tyrosine (Tyr) was detected at the HPMαFP/GCE by cyclic voltammetry. The mechanism and the best condition of electrode reaction were studied. The results indicate Tyr has an excellent electrochemical response at HPMαFP/GCE; under optimized experimental conditions, the peak current is proportional to the concentration of Tyr over a wide range. The linear regression equation at HPMαFP/GCE is IPa (µA) = 1.01134 + 0.96716 C (µmol · L?1) (r = 0.99914). The low detection limit is 1.6 × 10?7 mol · L?1. The modified electrode exhibited high sensitivity, good selectivity, and reproducibility, and it is easy to prepare. |