Abstract: | Abstract The electrochemical reduction of piroxicam has been investigated on a mercury pool in acidic and alcaline media. After exhaustive electrolysis, the extraction followed by chromatographic separation of the reaction products gives the reduced compounds which have been identified by spectroscopic techniques. From the analysis of the NMR 1H, 13C and IR spectra and the results of our preceding electrochemical investigation, the polarographic behaviour of piroxicam has been elucidated. The process occurs by the irreversible reduction of the double bond of the enol function over the total pH range investigated. However, in alkaline and highly acidic solutions, a preceding two-electron step occurs, giving rise to the opening of the thiazine ring. |