Reversed-Phase Ion-Pair Chromatography Of Antihistamine Drugs

Abstract

A reversed-phase ion-pair chromatographic separation of some antihistamine drugs is presented. The stationary phase consists of 1-pentanol or methylene-chloride adsorbed on a CH-10 column and the mobile phase of a phosphate buffer containing cyclohexylsulphamate and dimethyl-octylamine. It is concluded that this method is a valuable complement to a partition chromatographic method reported in an earlier publication.