| Abstract: | Abstract An isocratic HPLC method was developed and validated for the simultaneous determination of ibuprofen (IBU) and pseudoephedrine hydrochloride (PSE). Chromatography was carried out on an Apex phenyl column using 0.025 M acetic acid, triethylamine solution (pH 4.5) – acetonitrile (80:20, v/v) as mobile phase at a flow rate of 1 mL · min?1. UV detection was performed at a wavelength of 210 nm. The method was validated for specificity, linearity, accuracy, precision, and was successfully applied to pharmaceutical tablets of Rhinadvil®. |
