| Abstract: | Abstract Ratio subtraction and isosbestic point are two methods used to determine a mixture of almitrine dismesylate and raubasine. Linear correlations were obtained in the range from 4 to 18 µg ml?1 for almitrine dismesylate and 2 to 16 µg ml?1 for raubasine, with mean accuracies 99.87 ± 1.053 for almitrine dismesylate and 99.75 ± 1.301 for raubasine. Almitrine dismesylate and raubasine (II) in their mixtures were analyzed by the two methods where the total content was determined at the isosbestic point at 214.0 nm and raubasine was determined by ratio subtraction. The proposed methods were validated to be suitable for analysis of the pharmaceuticals. |
