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Chiral Resolution of Benzophenone Imine Derivatives of Amino Acid Esters on Chiral Stationary Phases
Abstract:Abstract

A convenient way of resolving the enantiomers of amino acid esters after their derivatization using benzophenone imine is described. The enantiomers of benzophenone Schiff base derivatives of various amino acid ethyl esters are readily separated on three commercially available chiral stationary phases (CSPs). Among them, CSPs 2 and 3 afford generally the base-line enantioresolution for the analytes studied. From understanding of chromatographic results, a plausible chiral recognition mechanism is discussed.
Keywords:Chiral stationary phases  Benzophenone imine derivatives  Amino Acid Esters  Enantiomer separation
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