Binary adduct formation of desipramine with dicarboxylic acids |
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Authors: | Adriana Ledeti Gabriela Vlase Titus Vlase Denisa Circioban Cristina Dehelean Ionut Ledeti Lenuta-Maria Suta |
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Affiliation: | 1.Faculty of Pharmacy,“Victor Babes” University of Medicine and Pharmacy,Timisoara,Romania;2.Research Center for Thermal Analysis in Environmental Problems, Faculty of Chemistry-Biology-Geography,West University of Timisoara,Timisoara,Romania |
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Abstract: | This paper presents the results obtained in a screening study for binary adduct formation of desipramine with three dicarboxylic acids—namely succinic, malonic and glutaric acids. Adduct formation is important because most tricyclic antidepressants show limited water solubility as free bases. Three binary adducts were prepared using a wet kneading method in non-homogenous media in presence of ethanol. Investigations of the solid state (ATR-FTIR, PXRD) and thermal analysis (TG/DTG/HF) were used for characterization of the prepared samples. The corroboration of data from employed instrumental techniques suggests that binary adducts in molar ratio 1:1 were obtained under the used experimental conditions. |
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