| Stereoselective Synthesis of α-Aminonitril on Glucose Templates |
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| 引用本文： | ZHANG Peng-Fei,GU Yi-Xin,GUO Jun-Li,CHEN Min.Stereoselective Synthesis of α-Aminonitril on Glucose Templates[J].有机化学,2003,23(Z1):90-92. |
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| 作者姓名： | ZHANG Peng-Fei GU Yi-Xin GUO Jun-Li CHEN Min |
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| 作者单位： | ZHANG Peng-Fei（Department of Chemistry, Hangzhou Teachers College, Zhejiang 310036）
GU Yi-Xin（Department of Chemistry, Hangzhou Teachers College, Zhejiang 310036）
GUO Jun-Li（Department of Chemistry, Hangzhou Teachers College, Zhejiang 310036）
CHEN Min（Department of Chemistry, Hangzhou Teachers College, Zhejiang 310036） |
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| 基金项目： | Project supported by the Natural Science Foundation of Zhejiang Province (No. 202075 ). |
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| 摘 要： | Both proteinogenic and non proteinogenic α-amino acids are of particular interest as constituents of peptide factors, peptidomimetics and antibiotics for the construction of modern selective drugs. 1] Furthemore, α-amino acid derivatives are interesting building units for chiral-pool syntheses of enantiomerically pure natural products. 2] Numerous efforts in modern organic synthesis are centered on the synthesis of enantiomerically pure α-amino acids. 3] During the past three decades efficient methods of asymmetric synthesis of α-amino acids have been developed; most of them are based on electrophilic transformations of organometallic intermediates. 4] Using the concept that the chirality of the carbohydrates can be exploited for diastereoselective reactions, Kunz and his cooperator had developed a Strecker synthesis with glycosyl amines as chiral auxiliaries. 5]
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Stereoselective Synthesis of α-Aminonitril on Glucose Templates |
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| ZHANG Peng-Fei,GU Yi-Xin,Guo Jun-li,CHEN Min.Stereoselective Synthesis of α-Aminonitril on Glucose Templates[J].Chinese Journal of Organic Chemistry,2003,23(Z1):90-92. |
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| Authors: | ZHANG Peng-Fei GU Yi-Xin Guo Jun-li CHEN Min |
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| Abstract: | Both proteinogenic and non proteinogenic α-amino acids are of particular interest as constituents of peptide factors, peptidomimetics and antibiotics for the construction of modern selective drugs. 1] Furthemore, α-amino acid derivatives are interesting building units for chiral-pool syntheses of enantiomerically pure natural products. 2] Numerous efforts in modern organic synthesis are centered on the synthesis of enantiomerically pure α-amino acids. 3] During the past three decades efficient methods of asymmetric synthesis of α-amino acids have been developed; most of them are based on electrophilic transformations of organometallic intermediates. 4] Using the concept that the chirality of the carbohydrates can be exploited for diastereoselective reactions, Kunz and his cooperator had developed a Strecker synthesis with glycosyl amines as chiral auxiliaries. 5] |
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