| 2,3,4,6-四-O-苄基井冈霉烯胺的合成 |
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| 引用本文： | 杨光丽,刘侠,张硕,杨劲松. 2,3,4,6-四-O-苄基井冈霉烯胺的合成[J]. 化学研究与应用, 2009, 21(5) |
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| 作者姓名： | 杨光丽 刘侠 张硕 杨劲松 |
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| 作者单位： | 四川大学华西药学院,四川,成都,610041;四川大学华西药学院,四川,成都,610041;四川大学华西药学院,四川,成都,610041;四川大学华西药学院,四川,成都,610041 |
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| 基金项目： | 国家自然科学基金面上项目 |
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| 摘 要： | 1972年,Kameda Y等人[1]从脱氮假单胞菌Pseudomonas denitrificans的降解产物中分离得到井冈霉烯胺(valienamine),其半椅式构象能模拟酶催化糖苷键水解的氧碳鎓正离子中间体(见图1),是a-葡萄糖苷酶抑制剂阿卡波糖、伏格列波糖的药效必需结构团.
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| 关 键 词： | 2 3 4 6-四-O-苄基井冈霉烯胺 D-葡萄糖 合成 |
Synthesis of tetra-O-benzylvalienamine |
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| YANG Guang-li,LIU Xia,ZHANG Shuo,YANG Jin-song. Synthesis of tetra-O-benzylvalienamine[J]. Chemical Research and Application, 2009, 21(5) |
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| Authors: | YANG Guang-li LIU Xia ZHANG Shuo YANG Jin-song |
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| Affiliation: | School of Pharmacy;Sichuan University;Chengdu 610041;China |
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| Abstract: | Tetra-O-benzylvalienamine was successfully synthesized by taking D-glucose as the starting material via a twelve-steps procedure in an overall yield of 4.7% in this paper.The structure of the title compound was confirmed by spectral analysis.This improved method could avoid the usage of some poisonous reagents,reduce the cost and increase the total yield. |
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| Keywords: | tetra-O-benzylvalienamine D-glucose synthesis |
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