School of Pharmacy, Lanzhou University, Lanzhou 730000, People’s Republic of China
Abstract:
Norcrocrassinone (1), a novel tetranorditerpenoid possessing a fused 6/6/5 ring system, was isolated from the roots of Croton crassifolius. The structure of 1 was elucidated by extensive spectroscopic methods and confirmed by single crystal X-ray diffraction. The anti-Alzheimer’s disease (AD) activity of 1 was evaluated using humanized Caenorhabditis elegans AD pathological model.