| Synthesis and Anti-HIV Activity of Trisubstituted （3＇R, 4＇R）-3＇,4＇-Di-O-（S）-camphanoyl-（＋）-c/s-khenactone （DCK） Analogs |
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| 作者姓名： | Chun Hong ZHAO Ting ZHOU Lan XIE Jing Yun LI Zuo Yi BAO Zhao Wen LOU Kuo Hsiung LEE |
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| 作者单位： | [1]Beijing Institute of Pharmacology ＆ Toxicology, Beijing 100850 [2]Department of Chemistry, Hubei University, Wuhan, Hubei 430062 [3]Beijing Institute of Microbiology ＆ Epidemiology,Beijing 100850 [4]School of Pharmacy, University of North Carolina at Chapel Hill,NC 27599, USA |
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| 摘 要： | To further explore the potential of DCK analogs as anti-HIV drug candidates, ten new tri-substituted （3＇R,4＇R）-3＇,4＇-di-O-（S）-camphanoyl-（＋）-cis-khellactone （DCK） derivatives （4-13） were designed, synthesized, and evaluated against HIV replication in MT4 cells and H9 lympho- cytes.
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| 关 键 词： | 抗HIV性 合成方法 药物 DCK 分子结构 |
| 收稿时间： | 2005-01-07 |
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