Fractionation of lyophilized MIBI kit for99mTc labeling |
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Authors: | M S Mansur A Mushtaq M Jehangir |
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Institution: | (1) Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan;(2) Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan;(3) Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan |
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Abstract: | Summary The lyophilized MIBI kit was dissolved in 1 ml sterile saline or 250<span style='font-size: 12.0pt;font-family:Symbol;mso-bidi-font-family:Symbol'>mg/ml
ascorbic acid and dispensed into 0.2 ml fractions, which were stored at -20 °C for 12 days. The solution was prepared by using
two different protection methods. In the first method evacuated vials were used for storage of fractionated solution while
in the second method an antioxidant agent, ascorbic acid was employed. The radiochemical impurity of 99mTc-MIBI in the unprotected fractions rises with time. Exclusion of air as well addition of ascorbic acid in fractionated solutions
gave very good results. The labeling efficiency and biodistribution of fractionated solutions was the same as the lyophilized
kit even after 12 days. |
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Keywords: | |
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