Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors |
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Authors: | Terence Davis Matthew C Dix Michal J Rokicki Amy JC Brook Caroline S Widdowson David Kipling Mark C Bagley |
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Affiliation: | 1. College of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an, Shaanxi, 710065, PR China 2. Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550002, PR China
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Abstract: | To develop more potent small molecules with enhanced free radical scavenger properties, a series of N-substituted isatin derivatives was synthesized, and the cytoprotective effect on the apoptosis of PC12 cells induced by H2O2 was screened. All these compounds were found to be active, and N-ethyl isatin was found with the most potent activity of 69.7% protective effect on PC12 cells. Structure-activity relationship analyses showed the bioactivity of N-alkyl isatins decline as the increasing of the chain of the alkyl group, furthermore odd-even effect was found in the activity, which is interesting for further investigation. |
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