| 新型环烷烯并嘧啶并噻唑-3-酮类化合物的合成 |
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| 引用本文： | 胡晓芬,冯亚青,苏琦. 新型环烷烯并嘧啶并噻唑-3-酮类化合物的合成[J]. 有机化学, 2005, 25(11): 1406-1409 |
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| 作者姓名： | 胡晓芬 冯亚青 苏琦 |
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| 作者单位： | 天津大学化工学院精细化工系,天津,300072 |
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| 摘 要： | 以环戊酮、环庚酮为起始原料合成的环烷烯并[1,2-d]嘧啶-2-硫酮(2)与氯乙酸、芳香醛反应, 合成具有潜在抗癌活性的稠合杂环化合物5-芳基-2,8-二芳亚甲基-2,3,6,7-四氢-5H,8H-环戊烯并[1,2-d]噻唑并[3,2-a]嘧啶-3-酮(3)以及5-芳基-2,10-二芳亚甲基-2,3,6,7,8,9-六氢-5H,10H-环庚烯并[1,2-d]噻唑并[3,2-a]嘧啶-3-酮(4). 3和4的结构经1H NMR, IR, MS分析确认.
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| 关 键 词： | 环烷烯并嘧啶并噻唑酮 稠合杂环化合物 合成 表征 |
| 收稿时间： | 2004-12-08 |
| 修稿时间： | 2005-05-30 |
Synthesis of Novel Cycloal-keno[1,2-d]thiazolo[3,2-a]pyrimidin-3-ones |
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| HU,Xiao-Fen,FENG,Ya-Qing,SU,Qi. Synthesis of Novel Cycloal-keno[1,2-d]thiazolo[3,2-a]pyrimidin-3-ones[J]. Chinese Journal of Organic Chemistry, 2005, 25(11): 1406-1409 |
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| Authors: | HU Xiao-Fen FENG Ya-Qing SU Qi |
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| Affiliation: | Department of Fine Chemicals, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 |
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| Abstract: | Two types of cycloalkeno[1,2-d]pyrimidin-2-thiones (2) reacted with chloroacetic acid and the appropriate aldehyde to give 5-aryl-2,8-bis(arylmethylene)-2,3,6,7-tetrahydro-5H,8H-cyclopenta[1,2-d]thi- azolo[3,2-a]pyrimidin-3-ones (3) and 5-aryl-2,10-bis(arylmethylene)-2,3,6,7,8,9-hexahydro-5H,10H-cyclo- hepta[1,2-d]thiazolo[3,2-a]pyrimidin-3-ones (4) respectively, which show potential anticancer activities. Structures of novel compounds 3 and 4 were determined by 1H NMR, IR and MS spectra. |
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| Keywords: | cycloalkeno[1,2-d]thiazolo[3,2-a]pyrimidin-3-one fused heterocyclics synthesis determination |
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