| Total Synthesis of （-）-Tetrahydrolipstatin by the Tandem Mukaiyama-aldol Lactonization |
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| 作者姓名： | Jian YIN Xiao Bo YANG Zai Xin CHEN Yi Hua ZHANG |
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| 作者单位： | [1]Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009 [2]Jiangsu Yabang Pharm. Res. ＆ Dev. Co., Ltd, Nanjing 210004 |
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| 基金项目： | Dedicated to Prof. Dr. Dieter Enders in RWTH Aachen on occasion of his 60^th birthday. |
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| 摘 要： | （-）-Tetrahydrolipstatin 1 was synthesized in three steps and 33.8% overall yield from aldehyde 6 by tandem Mukaiyama-aldol lactonization, which offered a concise, efficient and highly diastereoselective route to this antiobesity drug. We also presented a resolution method for preparation of the crucial intermediate, β- （t-butyldimethylsilyloxy）tetradecanal.
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| 关 键 词： | 丁间醇醛 内酯化 合成方法 乙醛 |
| 收稿时间： | 2005-03-14 |
Total Synthesis of (-)-Tetrahydrolipstatin by the Tandem Mukaiyama-aldol Lactonization |
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| Jian YIN Xiao Bo YANG Zai Xin CHEN Yi Hua ZHANG.Total Synthesis of (-)-Tetrahydrolipstatin by the Tandem Mukaiyama-aldol Lactonization[J].Chinese Chemical Letters,2005,16(11):1448-1450. |
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| Authors: | Jian;YIN;Xiao;Bo;YANG;Zai;Xin;CHEN;Yi;Hua;ZHANG |
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