RCM-mediated synthesis of trifluoromethyl-containing nitrogen heterocycles |
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Authors: | De Matteis Valeria van Delft Floris L Jakobi Harald Lindell Stephen Tiebes Jörg Rutjes Floris P J T |
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Affiliation: | Institute for Molecules and Materials, Radboud University Nijmegen, Toernooiveld 1, NL-6525 ED Nijmegen, The Netherlands. |
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Abstract: | A ring-closing metathesis mediated pathway to trifluoromethyl-containing piperidines is detailed. This involves the development of a synthetic route to a new (trifluoromethyl)allylating reagent via a Diels-Alder/retro-Diels-Alder strategy, its application in the synthesis of a series of trifluormethyl-substituted diolefin precursors for ring-closing metathesis, and eventually the successful cyclization of these precursor molecules into the corresponding functionalized piperidines. |
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