Expeditious reaction of ninhydrin with active methylene compounds on montmorillonite K10 clay |
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| Authors: | Manas Chakrabarty Ajanta Mukherji Shiho Arima Yoshihiro Harigaya Guillaume Pilet |
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| Affiliation: | (1) Department of Chemistry, Bose Institute, 93/1, A. P. C. Road, Kolkata, 700009, India;(2) School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108, Japan;(3) Laboratoire des Multi-matériaux et Interfaces, Groupe de Cristallographie et Ingénierie Moléculaire, UMB 5615 CNRS–Université Claude Bernard, Lyon 1, France |
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| Abstract: | Abstract Ninhydrin reacted expeditiously with thirteen active methylene compounds on montmorillonite K10 clay at room temperature to furnish, in 5 min, a Knoevenagel condensate in one case, aldols in six cases, aldol-derived cyclic hemiketals in three cases, and interesting products in the remaining three cases. Almost identical results were obtained, but faster, when the reactions were carried out in water on steam-bath. The structures of two novel products were also confirmed by single-crystal X-ray diffraction analysis. Graphical abstract  |
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| Keywords: | Ninhydrin Active methylene compounds Montmorillonite K10 clay Water Aldolization |
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