An unusual synthesis of tetrahydrobenzo[f]isoquinolines |
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| Authors: | Ramendra Pratap PR Maulik |
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| Institution: | a Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India
b Molecular and Structural Biology Division, Central Drug Research Institute, Lucknow 226 001, India |
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| Abstract: | A facile and short synthesis of 2-oxo-4-sec-amino-2,3,5,6-tetrahydrobenzof]isoquinoline-1-carbonitriles has been delineated through base catalyzed ring transformation of 5,6-dihydro-2-oxo-4-sec-amino-2H-benzoh]chromene-3-carbonitrile by cyanoacetamide in excellent yields. |
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| Keywords: | 2-Oxo-4-(piperidin-1-yl)-5 6-dihydro-2H-benzo[h]-chromene-3-carbonitriles Ring transformation Benzo[f]-isoquinoline |
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