The catalytic tandem oxidation/benzilic ester rearrangement (BER): insights into reaction mechanism and stereoselectivity |
| |
| Authors: | Carolina Silva Marques,Anthony J. Burke,Olí via R. Furtado |
| |
| Affiliation: | a Departamento de Química and Centro de Química de Évora, Universidade de Évora, Rua Romão Romalho 59, 7000 Évora, Portugal
b Departamento de Tecnologia de Indústrias Químicas, Instituto Nacional de Engenharia, Tecnologia e Inovação, Estrada do Paço do Lumiar, Edifício F, 1649-038 Lisboa, Portugal |
| |
| Abstract: | This Letter describes an expeditious regiospecific and stereoselective approach to tertiary α-hydroxyesters via a simple one pot tandem catalytic oxidation/benzilic ester rearrangement of acyclic α-hydroxyketone substrates. Mechanistic studies confirming the regioselective nature of this reaction are discussed, including some insights into the nature of the stereoselectivity encountered in this reaction. |
| |
| Keywords: | Benzilic acid rearrangment Benzilic ester rearrangment Isotopic label Regioselectivity Diastereoselectivity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
