Palladium-catalyzed synthesis of 2-substituted benzothiazoles via a C-H functionalization/intramolecular C-S bond formation process |
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Authors: | Inamoto Kiyofumi Hasegawa Chisa Hiroya Kou Doi Takayuki |
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Institution: | Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Sendai, Japan. inamoto@mail.pharm.tohoku.ac.jp |
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Abstract: | Catalytic synthesis of 2-substituted benzothiazoles from thiobenzanilides was achieved in the presence of a palladium catalyst through C-H functionalization/C-S bond formation. This method features the use of a novel catalytic system consisting of 10 mol % of Pd(II), 50 mol % of Cu(I), and 2 equiv of Bu4NBr that produced variously substituted benzothiazoles in high yields with good functional group tolerance. |
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