Zinc-mediated allylation and alkylation of aminals in the presence of TMSCl and diisopropylamine |
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| Authors: | Hatano Bunpei Nagahashi Keita Kijima Tatsuro |
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| Affiliation: | Division of Chemistry, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, 992-8510, Japan. hatano@yz.yamagata-u.ac.jp |
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| Abstract: | An alkylation of aminals with organozinc reagents derived from allyl bromide, benzyl bromide, alpha-bromoacetate, and alpha-bromonitrile proceeded efficiently in the presence of TMSCl and diisopropylamine. This reaction system was applied to the synthesis of an antispasmodic: butaverine. |
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