Lanthanide(III) Complexes of Two Novel N 3 O 4 -donor Macrocycles Derived from 3,6-Dioxa-1,8-Octanediamine |
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| Authors: | Emilia Bertolo Rufina Bastida Carlos Lodeiro Adolfo Rodriguez |
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| Affiliation: | (1) Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis;(2) Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis;(3) Centro de Ciências Agro-Ambientais e de Alimentos, Universidade do Oeste de Santa Catarina, Chapecó-SC;(4) Departamento de Química Física, Faculdade de Ciências, Universidade de Santiago de Compostela, Lugo, 27002, Espanha |
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| Abstract: | Cyclodextrins are a group of cyclic oligosaccharides which have shown to improve pharmaceutical properties of drugs, such as solubility and stability, by forming inclusion complexes. Diloxanide furoate has direct amoebicide action on the intestinal lumen and little solubility in water. In this work, solubility, NMR, fluorescence techniques, and kinetic methods were used to determine the equilibrium constant for the formation of the  -cyclodextrin–diloxanide furoate complex, K1:1. It is shown that the kinetic approach is the best method for such a determination. |
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| Keywords: | ![]("</a) /content/x863134xqw3525xp/xxlarge946.gif" alt=" beta" align=" MIDDLE" BORDER=" 0" >-cyclodextrin diloxanide furoate inclusion complexes stability constant |
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