Syntheses of C-substituted icosahedral dicarbaboranes bearing the 8-dioxane-cobalt bisdicarbollide moiety |
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| Authors: | Václav Šícha Bohumil Štíbr Bohumír Grüner Clara Viñas |
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| Institution: | a Institute of Inorganic Chemistry, Academy of Sciences of the Czech Republic, 250 68 ?ez, Czech Republic
b Institut de Ciència de Materials de Barcelona (CSIC), Campus de la U.A.B., E-08193 Bellaterra, Spain |
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| Abstract: | The treatment of 1,2-, 1,7- and 1,12-carbaborane lithiated isomers with 3,3′-Co-8-(CH2CH2O)2-(1,2-C2B9H10)-(1′,2′-C2B9H11)] (1) at molar ratios 1:1 or 1:2 at room temperature in THF leads generally to the formation of a series of orange double-cluster mono and dianions. These were characterized by NMR and MS methods as 1′′-X-1′′,2′′-closo-C2B10H11]−, 2]−; 1′′-X-1′′,7′′-closo-C2B10H11]−, 3]− and 1′′-X-1′′,12′′-closo-C2B10H11], 4]− for the monoanions, whereas 1′′,2′′-X2-1′′,2′′-closo-C2B10H10]2−, 2]2−; 1′′,7′′-X2-1′′,7′′-closo-C2B10H10]2−, 3]2−; and 1′′,12′′-X2-1′′,12′′-closo-C2B10H10]2−, 4]2− for the dianions (where X = 3,3′-Co-8-(CH2CH2O)2-(1,2-C2B9H10)-1′,2′-(C2B9H11)). Moreover, these borane-cage subunits can be easily modified via attaching variable substituents onto cage carbon and boron vertices, which makes these compounds structurally flexible potential candidates for BNCT of cancer and HIV-PR inhibition. |
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| Keywords: | Carborane Metallacarborane Ring-opening BNCT Polyanion |
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