Microsphaerins A–D, four novel benzophenone dimers with activity against MRSA from the fungus Microsphaeropsis sp. |
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| Authors: | K Yoganathan Shugeng Cao Sharon C Crasta Srinivasulu Aitipamula Stephen R Whitton Siewbee Ng Antony D Buss Mark S Butler |
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| Institution: | aMerLion Pharmaceuticals, 1 Science Park Road, The Capricorn #05-01, Singapore Science Park II, 117528, Singapore;bInstitute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, 627833, Singapore |
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| Abstract: | Bioassay-guided isolation using an MRSA whole cell assay yielded four novel benzophenone dimers, microsphaerins A–D (1–4), from two Singapore isolates of the soil anamorph Microsphaeropsis sp. The structures of 1–4 were elucidated on the basis of spectral data and the structures of 1 and 4 were confirmed by X-ray crystallographic analyses. |
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| Keywords: | Benzophenone Dimers MRSA Microsphaeropsis NMR |
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