Diastereomeric separation of α-amino acid derivatives using a chiral carbodiimide |
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| Authors: | Hideaki Kasimura Keiki Kishikawa Shigeo Kohmoto Makoto Yamamoto Kazutoshi Yamada |
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| Affiliation: | Department of Industrial Chemistry, Faculty of Engineering, Chiba University, 1-33 Yayoi-cho, Chiba-shi, Chiba 260 Japan |
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| Abstract: | N,N′-Bis[(S)-1-phenylethyl]carbodiimide (1) was found to be an efficient chiral derivatizing agent for the diastereomeric separation of 2-N-benzyloxycarbonylamino acids (2). Diastereomeric acylureas prepared from 1 and 2 showed a large chromatographic selectivity (α). Their capacity factors and selectivity depend on the carbon chain length of the α-alkyl substituents of acylureas. |
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| Keywords: | Amino acids Chiral derivatization Carbodiimides Ivory identification |
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