Adsorptive stripping voltammetric determination of midazolam as a method for quality control |
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Authors: | S. Kir A.N. Onar A. Temizer |
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Affiliation: | Department of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100 Ankara Turkey |
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Abstract: | Controlled interfacial accumulation of the benzodiazepine midazolam at a hanging mercury drop electrode provides the basis for a highly sensitive and accurate adsorptive stripping voltammetric procedure. The response was linear in the range 1.9 × 10?6? × 10?9 M when using a 120-s preconcentration at ?0.45 V vs. Ag/AgCl in Britton-Robinson buffer of pH 5.00. In this range the relative standard deviation was between 1.21 and 1.62%. The applicability of the method to pharmaceutical preparations is discussed. |
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