Electrochemical determination of allopurinol based on its interaction with xanthine oxidase |
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| Authors: | Glenn B Martin Garry A Rechnitz |
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| Institution: | Hawaii Biosensor Laboratory, Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822 U.S.A. |
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| Abstract: | Allopurinol was determined in the range 0.20–50 μM utilizing xanthine oxidase immobilized onto a carbon paste electrode. Alternative assay methods relying on either inhibition of enzymatic activity or direct formation of a product are evaluated. Regeneration of xanthine oxidase activity under various conditions is also surveyed. |
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| Keywords: | Allopurinol Enzyme electrode Biosensor |
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