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Study on biodegradability of poly(amide-imide)s containing N-trimellitylimido-L-amino acids and 3,5-diamino-N-(pyridin-3-yl)benzamide linkages |
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| Authors: | S Mallakpour H Ayatollahi M R Sabzalian |
| Institution: | 1. Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran 2. Nanotechnology and Advanced Materials Institute, Isfahan University of Technology, Isfahan, 84156-83111, Iran 3. Center of Excellence in Sensors and Green Chemistry, Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran 4. College of Agriculture, Department of Agronomy and Plant Breeding, Isfahan University of Technology, Isfahan, 84156-83111, Iran |
| Abstract: | A series of novel biodegradable functional amino acid-based poly(amide-imide)s (PAI)s were designed and synthesized by the direct polycondensation reaction of chiral bioactive diacids composed of naturally occurring α-amino acids with 3,5-diamino-N-(pyridin-3-yl) benzamide in the presence of molten tetrabutylammonium bromide as a green solvent. These new biodegradable polymers were characterized with Fourier transfer infrared and 1H NMR spectroscopy, field emission scanning electron microscopy. In addition, in vitro toxicity and biodegradability behavior of the starting diacids, diamine and obtained PAIs were investigated in culture media and the results showed that the synthesized monomers and their derived polymers are biologically active and their degradation products are probably nontoxic to microbial growth. |
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