Five unusual natural carbohydrates from Actinosynnema pretiosum |
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| Authors: | Chunhua Lu Linquan Bai Yuemao Shen |
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| Affiliation: | (1) Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering; Xiamen Engineering Research Center of Marine Microbial Drug Discovery; Fujian Laboratory of Pharmaceutical Engineering; School of Life Science, Xiamen University, Xiamen, Fujian, 361005, P. R. China;(2) Bio-X Life Science Research Center, Shanghai Jiaotong University, Shanghai, 200030, China |
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| Abstract: | Five unusual hexose derivatives were isolated from the carbohydrate portion of the solid-state fermentation extract of Actinosynnema pretiosum ssp. auranticum ATCC 31565, which is a producing strain of maytansinoids that are a family of 19-membered macrocyclic lactams having extraordinary cytotoxic and antineoplastic activities. Their structures were determined to be 2-deoxy-α-D-arabino-hexopyranose (1), 2-deoxy-β-D-arabino-hexopyranose (2), 3,6-anhydro-2-deoxy-α-D-arabino-hexcofuranose (3), 3,6-anhydro-2-deoxy-β-D-arabino-hexofuranose (4), and 2-(D-glycerol-1,2-dihydroxyethyl)furan (5) by NMR spectroscopic experiments. Published in Khimiya Prirodnykh Soedinenii, No. 5, pp. 481–483, September-October, 2008. |
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| Keywords: | Actinosynnema pretiosum ssp. auranticum ATCC 31565 2-deoxyglucose (2-DG) 3,6-anhydro-2-deoxyglucose 2-(D-glycerol-1,2-dihydroxyethyl)furan |
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