Amphiphilic Linear-Branched Copolylactides and Disperse Systems on Their Basis |
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Authors: | V. V. Istratov V. I. Gomzyak T. V. Krupina V. A. Vasnev S. N. Chvalun |
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Affiliation: | 1.Nesmeyanov Institute of Organoelement Compounds,Russian Academy of Sciences,Moscow,Russia;2.Moscow Technological University,Moscow,Russia |
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Abstract: | The linear-branched copolylactides containing linear side poly(ethylene oxide) blocks are synthesized and characterized. The critical micelle concentrations and the aggregative stability and the dispersity of oil/water emulsions stabilized by these copolymers are estimated. The polylactide microparticles are obtained by emulsification followed by evaporation of an organic solvent using acetylsalicylic acid as a model drug. The structure of copolylactides strongly affects the properties of the microparticles. On one hand, the presence of large poly(ethylene oxide) blocks in the linear-branched macromolecules leads to the formation of colloidal systems with a higher aggregative stability of emulsions and a lower size of particles, and on the other hand, the microparticles formed from these copolymers possess a lower incorporation efficiency relative to water-soluble low-molecular-mass compounds and the profile of the release of these compounds is nonlinear and contains the region of accelerated release. |
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