Biocompatibility and <Emphasis Type="Italic">in vitro</Emphasis> antineoplastic drug-loaded trial of titania nanotubes prepared by anodic oxidation of a pure titanium |
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| Authors: | XiLin Xiao LiXia Yang ManLi Guo ChunFeng Pan QingYun Cai ShouZhuo Yao |
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| Institution: | (1) World Class University (WCU) Program of Chemical Convergence for Energy Environment (C2E2), School of Chemical Biological Engineering, Seoul National University, Seoul, 151-744, Korea;(2) Department of Chemistry Education, Chonnam National University, Gwangju, 500-757, Korea;(3) School of chemical and Biological Engineering and Interdisciplinary Program in Nano Science and Technology, Seoul National University, Seoul, 151-742, Korea |
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| Abstract: | TiO2 nanotube (NT) arrays have been prepared by anodic oxidation of a Ti sheet, and carbon-deposited TiO2 NT arrays have been prepared by annealing TiO2 NT arrays in carbon atmosphere. The biocompatibility of the as-prepared NT arrays was investigated by observing the growth
of osteosarcoma (MG-63) cells on the NT arrays. The application of the TiO2 NT arrays as a drug delivery vehicle was investigated. Both the TiO2 NTs and the carbon-modified TiO2 NTs have good biocompatibility supporting the normal growth and adhesion of MG-63 cells with no need of extracellular matrix
protein coating. The one end-opened TiO2 NTs can be easily filled with drugs, working as an efficient drug delivery vehicle. |
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